Researchers Working On Vaccine For Those With Celiac Disease

Apr 10, 2017, 01:08
Researchers Working On Vaccine For Those With Celiac Disease

The protein gluten is commonly an element present in wheat and rye, and a wrong response of the organism may lead to severe damages within the intestinal lining. "That's why we believe that once we have more studies, we may want to think about whether children at high risk of developing celiac disease should be vaccinated", said senior author Bana Jabri in a statement. Currently, there are no known cures for this celiac condition but for the patient to have a gluten-free diet regime.

An estimated 40 percent of the population have the genes that predispose them to celiac disease, but while 95 percent of people eat gluten, only 1 percent end up developing the disorder, said Dr. Paul Green, director of the Celiac Center at Columbia University in NY. People with celiac disease had more antibodies to reoviruses in their blood compared to healthy individuals.

Celiac disease affects around 1 in every 133 individuals in the country, although only about 17 percent are diagnosed with the ailment. Those who got infected with the reovirus were likely to have an immune reaction regarding gluten compared to mice which were not infected with the bad virus.

As such, the study co-author notes that it is important to recognize how a reovirus infection can leave a "permanent mark" on the immune system, which can increase the risk for developing celiac disease.

For people with celiac disease, gluten can wreak havoc on their digestive systems.

They found that both T1L and T3D could trigger protective immune responses - activating the immune system to attack anything foreign it can find - but only T1L caused the mice's immune systems to act against gluten, triggering a celiac-like condition.

"Epidemiologic studies show infection could be a trigger but no-one's ever really shown how that would happen".

According to the investigation, viruses may be responsible for triggering several conditions like type 1 diabetes and the celiac disease itself. In the studies in which lab mice were tested, experts discovered that IRF1 had a vital role in the development of gluten intolerance after the mouse was infected with reovirus.

Celiac disease is also referred to as celiac sprue, gluten-sensitive enteropathy, nontropical sprue and coeliac disease.

According to the Centers for Disease Control and Prevention, at least 3 million Americans have celiac disease, with 97 percent undiagnosed.

The study also found that coeliac disease patients had much higher levels of antibodies against reoviruses than people without the disease.

Gluten's a dietary protein that's found in many modern grains, and our body struggles to digest it, which means it's more likely than other proteins to trigger allergies or an immune response.

Since reovirus silently changes the body's natural immune response, researchers propose that after the initial infection the body begins building up an anti-gluten army.

The initial viral infection may set the stage for affliction with celiac disease at a later point in the child's life. This could protect children from conditions like the celiac disease and other autoimmune disorders. Maybe, in the future we might even develop a reovirus vaccine to help block coeliac disease from beginning.